Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus

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Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory.

Acid-sensing ion channel-1a (ASIC1a) is localized in brain regions with high synaptic density and is thought to contribute to synaptic plasticity, learning, and memory. A prominent hypothesis is that activation of postsynaptic ASICs promotes depolarization, thereby augmenting N-methyl-d-aspartate receptor function and contributing to the induction of long-term potentiation (LTP). However, evide...

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Objective(s): Activation of acid-sensing ion channel 1a (ASIC1a) is responsible for tissue injury caused by acidosis in nervous systems. But its physiological and pathological roles in nucleus pulposus cells (NPCs) are unclear. The aim of this study is to investigate whether ASIC1a regulates the survival of NPCs in the acidic environment of degenerated discs. Materials and Methods: NPCs were i...

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Trypsin cleaves acid-sensing ion channel 1a in a domain that is critical for channel gating.

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ژورنال

عنوان ژورنال: Pharmacological Research

سال: 2017

ISSN: 1043-6618

DOI: 10.1016/j.phrs.2017.01.028